Hostile towards mankind

Ishmael was a child from Abraham. Abraham doubted God so he had Ishmael. The line of the Messiah will come from Issac.
Ishmael didn't honor the God of the Bible so his sinful nature was in control. He was married and had children. His children were hostility towards his relatives. When we are slaves to our sins then there is no peace.
When I refuse to follow Jesus then I will become a fool. My sins will expose folly. 
I need to follow Jesus. I need to ask for the Lord, I need a new heart. 
If a person have Jesus, there will have a new nature. But if they don't focus on the Lord, then that person will do many sins.
If a person don't have Jesus, then that person is a slave to their sins. That person needs to kill the sinful nature on the cross of Jesus.

 

Genesis 25:12-18

 

¹² This is the account of the family line of Abraham’s son Ishmael, whom Sarah’s slave, Hagar the Egyptian, bore to Abraham.
¹³ These are the names of the sons of Ishmael, listed in the order of their birth: Nebaioth the firstborn of Ishmael, Kedar, Adbeel, Mibsam, ¹⁴ Mishma, Dumah, Massa, ¹⁵ Hadad, Tema, Jetur, Naphish and Kedemah. ¹⁶ These were the sons of Ishmael, and these are the names of the twelve tribal rulers according to their settlements and camps. ¹⁷ Ishmael lived a hundred and thirty-seven years. He breathed his last and died, and he was gathered to his people. ¹⁸ His descendants settled in the area from Havilah to Shur, near the eastern border of Egypt, as you go toward Ashur. And they lived in hostility toward  all the tribes related to them.