These words are interesting and God knew that Jacob was God's chosen person before Jacob was born.
The will of the Lord will happen even if mankind want to destroy the will of the Lord.
God is the great checker player that always wins every game.
God knew Jacob would be his chosen person so he was appointed. Esau was hunting for food and he would prepare a meal for Isaac. Jacob will trick Isaac for the blessing but God knew that Jacob was the chosen person for God's plan.